Blocks opioid receptors, it eliminates the central (including respiratory depression) and peripheral effects of opioids. Also affects the dopaminergic and testosterone enanthate system of the brain. There is no tolerance and drug dependence. Persons with drug dependence provokes the development of withdrawal symptoms.
In experiments on mice and rats found suppression of fertility and no teratogenic effect.
The half-life of naloxone – 30-80 minutes. Excreted by the kidneys (for 72 hours to return 70% of the administered dose).
- Overdose of narcotic analgesics.
- Postoperative use: acceleration out of general anesthesia, before the end of controlled breathing. Postoperatively the drug is used only if in narcotic analgesics were used during anesthesia. Naloxone is not effective for the treatment of respiratory depression caused by substances other than opioids.
- Restore breathing in newborns, after the introduction of maternity narcotic analgesics.
- As a diagnostic drug for patients with a suspected drug addiction.
Organic heart disease, pulmonary disease, renal / hepatic insufficiency, the use of narcotic analgesics in high doses, physically dependent on opioids, children’s age, the use in newborns from mothers with opioid dependence.
Pregnancy and lactation
Use during pregnancy is acceptable if the benefit to the mother outweighs the risk to the fetus. It is unknown whether naloxone is testosterone enanthate side effects excreted in breast milk. Use of the drug during breastfeeding possible for absolute indications.
Dosing and Administration
The drug is administered intravenously, intramuscularly, subcutaneously.
With an overdose of narcotic analgesics for adults – at a dose of 0.4-2 mg, children – 5-10 mg / kg. When used in this dose did not bring the expected effect, administering the same dose was repeated after 2-3 min. The maximum cumulative dose – 10 mg / day. If the recovery of consciousness and breathing does not occur, it is necessary to think of other (non-opioid) due to poisoning.
Postoperative administration is carried out intravenously, at a dose of 0.1-0.2 mg after 2-3 minutes of administration of the same dose is repeated until a satisfactory recovery in a patient breathing. Then within a few hours if necessary continue intramuscular administration.
In children, the initial dose intravenously -1-2 mg / kg. If the desired effect is not reintroduced at doses up to OD mg / kg every 2 min until recovery of spontaneous breathing and consciousness. If unable to intravenous administration can be administered intramuscularly or subcutaneously in divided doses.
Newborns initial dose – 0.01 mg / kg. Introduction can be repeated in accordance with the principles of adult use.
If respiratory testosterone enanthate depression, caused by the introduction of opioid analgesics mother during childbirth, newborns are administered 0.1 mg / kg intramuscularly, subcutaneously or intravenously. Before the introduction, make sure the airway in the newborn. Perhaps prophylactic intramuscular 0.2 mg (0.06 mg / kg).
Diagnosis of opioid dependence – 0.08 mg intravenously.
From the digestive system: nausea, vomiting. Cardio-vascular system: tachycardia, arrhythmia, increased or decreased blood pressure.
After the introduction in doses exceeding therapeutic, (especially in the postoperative period in patients with diseases of the cardiovascular system): the disappearance of analgesia and arousal, decreased / increased blood pressure, ventricular paroxysmal tachycardia, ventricular fibrillation, pulmonary edema, cardiac arrest.
CNS: tremor, nervousness, agitation, irritability, fatigue, seizures, behavioral disorders.
Other: increased sweating, allergic reactions, pulmonary edema.
The syndrome of “cancellation” in patients with opioid dependence: vague pain, diarrhea, pyrexia, rhinorrhea, sneezing, “goose bumps”, sweating, nausea, vomiting, nervousness, fatigue, irritability, tremors, spasms in the epigastric region, tachycardia, weakness; in newborns – cramps, diarrhea, pyrexia, uncontrolled crying, hyperreflexia, sneezing, tremors, unusual irritability, vomiting.
Interaction with other drugs
- Reduces the hypotensive effect of clonidine.
- Reduces the effect of narcotic analgesics (including butorphanol, nalbuphine, pentazocine, fentanyl, remifentanil), and accelerates the appearance syndrome “cancel.”
- Incompatible with testosterone enanthate solutions of drugs containing hydrogen sulfates.
- Pharmaceutically compatible with 0.9% sodium chloride solution, 5% dextrose, sterile water for injection.
May be used as a medicament for the differential diagnosis of poisoning by narcotic analgesics. In the application it is necessary to carry out constant medical supervision of the patient.
Solution for injection 0.4 mg / ml in 1 ml ampoules.
5 ampoules in blisters of PVC film and aluminum foil lacquered or printed flexible packaging based on aluminum foil or without foil.
On 1 or 2 blisters (with foil or without foil), together with instructions for use of the drug, with a knife or lancet ampoule is placed in a pile of cardboard.When packing vials of rings or dots fracture scarifiers or knives ampoule do not invest. cut mix 150 female bodybuilding workout bodybuilding shirt