Tamoxifen Citrate is a Selective Estrogen Receptor Modulator (SERM) that was created in 1961 by ICI now known as AstraZenaca. There are numerous brands including generic forms of Tamoxifen Citrate on the market, but Nolvadex is the most well known. Often referred to as an anti-estrogen, Tamoxifen Citrate is actually both an antagonist and agonist. This means it will act as an anti-estrogen in certain areas of the body while acting as an estrogen in other areas.
Tamoxifen Citrate has been used medically for decades and has been highly successful in breast cancer treatment, specifically hormone-responsive breast cancer. It is also a medication that is used by many anabolic steroid users, but it is not a steroid. This is a drug steroid users will sometimes use during steroid use to help with estrogenic related side effects brought on by specific steroids. However, it is most commonly used during Post Cycle Therapy (PCT). PCT is the 3-6 week period following steroid use that is implemented in order to help with natural testosterone production that is suppressed during anabolic steroid use.
Tamoxifen Citrate Functions & Traits
Tamoxifen Citrate is a SERM that acts as both antagonist and agonist in relation to the estrogen hormone. It is an anti-estrogen in that it binds to estrogen receptors in certain parts of the body, particularly in the mammary tissue. This action prevents estrogen from acting on its originally intended point of binding. This makes Tamoxifen Citrate valuable to breast cancer patients as breast cancer feeds off of estrogen. And it’s valuable to steroid users as increased estrogen levels can bind to the mammary tissue and lead to gynecomastia.
The relationship Tamoxifen Citrate has in being an anti-estrogen is fairly straightforward and well understood by many, but it’s its relationship to being an estrogen in other areas that’s surprising to some. Tamoxifen Citrate acts as an estrogen on the liver. Liver related estrogenic activity has been shown to improve cardiovascular health, particularly as it relates to cholesterol. This can be very advantageous for the bodybuilding steroid user as most steroids have a negative impact on cholesterol levels.
Beyond its estrogen related activity Tamoxifen Citrate possesses strong testosterone stimulating properties. The use of Tamoxifen Citrate will stimulate the pituitary to increase its production of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) with a strong emphasis on LH. LH and FSH are the gonadotropins that signal to the testicles to produce testosterone. Without LH and FSH there is no testosterone production.